Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding

Chem Commun (Camb). 2017 Jul 20;53(59):8276-8279. doi: 10.1039/c7cc03991c.


Significant enhancement of single-molecular binding to a miRNA target and bidentate and asymmetric conjugation of two distinct thiolated DNA strands to single gold nanoparticles (AuNPs) were visibly demonstrated, by introducing two groups of ligands into our nanomechanical DNA origami devices (DNA pliers) to construct allosterically controllable systems.

MeSH terms

  • Binding Sites
  • Biomechanical Phenomena*
  • DNA / chemistry*
  • Gold / chemistry*
  • Ligands
  • Metal Nanoparticles / chemistry*
  • MicroRNAs / chemistry*
  • Microscopy, Atomic Force
  • Nanotechnology / methods*


  • Ligands
  • MicroRNAs
  • Gold
  • DNA