Evaluation of Compatibility of a Gum Mastic Liquid Adhesive and Liquid Adhesive Remover With an Alcoholic Chlorhexidine Gluconate Skin Preparation

J Infus Nurs. 2017 Jul/Aug;40(4):245-252. doi: 10.1097/NAN.0000000000000230.


The compatibility of a 2% chlorhexidine gluconate/70% isopropyl alcohol (CHG/IPA) skin preparation with a gum mastic liquid adhesive (GMLA) and liquid adhesive remover (LAR) was assessed in healthy volunteers. Twenty subjects completed test material combination with microbial sampling at 3- and 7-day time points. Mean log10 reductions from baseline for normal flora were assessed. There was no significant difference in reduction of normal flora on skin prepped with CHG/IPA versus skin prepped with CHG/IPA followed by GMLA or LAR. The conclusion of the study was that the use of GMLA or LAR with CHG/IPA does not affect the antiseptic effectiveness of CHG/IPA.

Publication types

  • Evaluation Study

MeSH terms

  • Adhesives* / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Bandages / microbiology
  • Chlorhexidine / analogs & derivatives*
  • Chlorhexidine / pharmacology
  • Colony Count, Microbial / methods
  • Healthy Volunteers
  • Humans
  • Infection Control
  • Mastic Resin*
  • Skin / microbiology*


  • Adhesives
  • Anti-Bacterial Agents
  • Mastic Resin
  • chlorhexidine gluconate
  • Chlorhexidine