Energy Sparing Orexigenic Inflammation of Obesity

Cell Metab. 2017 Jul 5;26(1):10-12. doi: 10.1016/j.cmet.2017.06.013.

Abstract

The neuro-immune interactions that integrate host metabolism in health and disease are unclear. A new study by Valdearcos et al. (2017) describes how sensing of high-fat diet by microglia, brain's resident innate immune cells, recruits additional bone-marrow-derived myeloid cells into the hypothalamus to produce inflammation and cause weight gain.

Keywords: Inflammation; NF-κB; hypothalamus; microglia; obesity.

MeSH terms

  • Animals
  • Diet, High-Fat / adverse effects*
  • Energy Metabolism*
  • Humans
  • Hypothalamus / metabolism
  • Hypothalamus / pathology
  • Inflammation / complications*
  • Inflammation / metabolism
  • Inflammation / pathology
  • Microglia / metabolism
  • Microglia / pathology*
  • Myeloid Cells / metabolism
  • Myeloid Cells / pathology*
  • NF-kappa B / metabolism
  • Obesity / complications*
  • Obesity / metabolism
  • Obesity / pathology

Substances

  • NF-kappa B