Biosynthesis of vitamin C stabilized tin oxide nanoparticles and their effect on body weight loss in neonatal rats

Environ Toxicol Pharmacol. 2017 Sep;54:48-52. doi: 10.1016/j.etap.2017.06.013. Epub 2017 Jun 20.


The green synthesis of tin oxide nanoparticles (SnO2 NPs) using vitamin C (Vc) as a reducing agent via a biosynthetic approach is described. The effect of Vc-stabilized SnO2 NPs on the body weight of neonatal rats is also studied. The prepared SnO2NPs were characterized using spectroscopic and microscopic instrumental techniques including transmission electron microscopy (TEM), UV-visible spectrophotometry (UV-vis), X-ray diffraction and Fourier transform infrared spectroscopy, which confirmed the formation of NPs. TEM images confirmed the formation of spherical NPs with a mean particle size of around 30nm. The body weight studies showed that vitamin-C stabilized SnO2 NPs promote a higher body weight gain compared to raw SnO2 NPs. It was also shown that Vc can counteract the decreased body weight caused by SnO2 NPs in neonatal rats.

Keywords: Body weight; SnO(2) NPs; Vitamin C.

MeSH terms

  • Animals
  • Animals, Newborn
  • Antioxidants* / chemistry
  • Antioxidants* / pharmacology
  • Ascorbic Acid* / chemistry
  • Ascorbic Acid* / pharmacology
  • Body Weight
  • Female
  • Green Chemistry Technology
  • Male
  • Metal Nanoparticles* / chemistry
  • Metal Nanoparticles* / ultrastructure
  • Microscopy, Electron, Transmission
  • Rats, Sprague-Dawley
  • Spectroscopy, Fourier Transform Infrared
  • Tin Compounds* / chemistry
  • Tin Compounds* / pharmacology


  • Antioxidants
  • Tin Compounds
  • stannic oxide
  • Ascorbic Acid