Neurotoxicity of fragrance compounds: A review

Environ Res. 2017 Oct:158:342-349. doi: 10.1016/j.envres.2017.06.035. Epub 2017 Jul 3.


Fragrance compounds are chemicals belonging to one of several families, which are used frequently and globally in cosmetics, household products, foods and beverages. A complete list of such compounds is rarely found on the ingredients-list of such products, as "fragrance mixtures" are defined as "trade secrets" and thus protected by law. While some information regarding the general toxicity of some of these compounds is available, their neurotoxicity is known to a lesser extent. Here, we discuss the prevalence and neurotoxicity of fragrance compounds belonging to the three most common groups: phthalates, synthetic musks and chemical sensitizers.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Allergens / toxicity*
  • Animals
  • Fatty Acids, Monounsaturated / toxicity*
  • Humans
  • Neurotoxins / toxicity*
  • Perfume / toxicity*
  • Phthalic Acids / toxicity*


  • Allergens
  • Fatty Acids, Monounsaturated
  • Neurotoxins
  • Perfume
  • Phthalic Acids
  • musk