The Clinical Evaluation of Angioedema

Immunol Allergy Clin North Am. 2017 Aug;37(3):449-466. doi: 10.1016/j.iac.2017.04.007.


The clinical evaluation of angioedema is reliant on obtaining a thorough patient and family history with an assessment of risk factors and presenting symptoms unique to each subtype. It is important to distinguish between angioedema with and without urticaria as a primary step in the evaluation; thereafter, laboratory parameters and investigations allow for subsequent stratification. There is a significant disease burden associated with angioedema and thus it is essential for health care practitioners to establish a prompt and accurate diagnosis, and a comprehensive care plan that addresses the patient's physical and mental well-being alike.

Keywords: Angioedema; Bradykinin; Hereditary angioedema; Histamine.

Publication types

  • Review

MeSH terms

  • Angioedema / diagnosis*
  • Angioedema / etiology
  • Angioedema / metabolism
  • Bradykinin / metabolism
  • Diagnosis, Differential
  • Genetic Predisposition to Disease
  • Histamine / metabolism
  • Humans
  • Immune System / cytology
  • Immune System / immunology
  • Immune System / metabolism
  • Immunoglobulin E / immunology
  • Signal Transduction
  • Symptom Assessment


  • Immunoglobulin E
  • Histamine
  • Bradykinin