trans-Lycopene from tomato juice attenuates inflammatory biomarkers in human plasma samples: An intervention trial

Mol Nutr Food Res. 2017 Nov;61(11). doi: 10.1002/mnfr.201600993. Epub 2017 Aug 28.


Scope: The effect of carotenoids from tomato juice (TJ) on inflammatory biomarkers was evaluated by performing a 4-week dose-response nutritional trial in a population at high cardiovascular risk.

Methods and results: An open, prospective, randomized, cross-over, and controlled clinical trial was carried out with 28 volunteers (mean age 69.7 ± 3.1 years; mean BMI 31.5 ± 3.6 kg/m2 ) at high cardiovascular risk, which were assigned to consume daily for 4 weeks in random order: 200 mL (LD) or 400 mL (HD) of TJ, or water as a control (C), with a 21-day wash-out period between each intervention. Blood samples were collected at baseline (B) and after each intervention. Endpoints included significant changes in plasmatic carotenoids, and adhesion molecules ICAM-1, and VCAM-1, as well as a tendency to decrease the chemokine IL-8. Compared to C, concentration of ICAM-1, and VCAM-1 were significantly lower (p ˂ 0.001), after each TJ intervention. Decreases were correlated remarkably with the trans-lycopene, while the other carotenoids present in TJ have presented a minor association or no association with changes in these molecules.

Conclusion: trans-Lycopene from TJ may attenuate the risk of cardiovascular disease by reducing the concentration of important inflammatory molecules related to atherosclerosis.

Keywords: Atherosclerosis; Cellular adhesion molecules; Inflammation; Tomato juice; trans/cis-Lycopene isomers.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / analysis
  • Anti-Inflammatory Agents, Non-Steroidal / blood
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Atherosclerosis / epidemiology
  • Atherosclerosis / etiology
  • Atherosclerosis / immunology
  • Atherosclerosis / prevention & control*
  • Biomarkers / blood
  • Body Mass Index
  • Carotenoids / analysis
  • Carotenoids / blood
  • Carotenoids / therapeutic use*
  • Cross-Over Studies
  • Follow-Up Studies
  • Fruit and Vegetable Juices* / analysis
  • Functional Food / analysis
  • Humans
  • Inflammation Mediators / blood*
  • Intercellular Adhesion Molecule-1 / blood
  • Lycopene
  • Lycopersicon esculentum* / chemistry
  • Middle Aged
  • Obesity / blood
  • Obesity / diet therapy*
  • Obesity / immunology
  • Obesity / physiopathology
  • Risk
  • Spain / epidemiology
  • Stereoisomerism
  • Vascular Cell Adhesion Molecule-1 / blood


  • Anti-Inflammatory Agents, Non-Steroidal
  • Biomarkers
  • ICAM1 protein, human
  • Inflammation Mediators
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • Carotenoids
  • Lycopene