Wound healing is a fundamental physiological progress to keep the integrity of the skin. The transition from inflammation to proliferation is a critical step during skin wound repair process. Impairment of this transition has been known as a common dominator in the pathophysiology of chronic non-healing wounds. MicroRNAs (miRNAs) are short non-coding RNAs regulating gene expression. Emerging evidence has revealed that miRNAs play important roles in both normal skin wound healing and in the pathogenesis of chronic wounds. We focus on the miRNAs regulating the inflammation-proliferation transition during wound healing and propose that these miRNAs may be promising targets for development of more effective wound therapy.
Keywords: chronic wound; inflammation; microRNA; proliferation; skin wound healing.