A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

Nature. 1986 Feb 27-Mar 5;319(6056):743-8. doi: 10.1038/319743a0.


A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Transformation, Neoplastic
  • Cloning, Molecular
  • DNA / analysis
  • Humans
  • Oncogenes*
  • Poly A / analysis
  • Protein-Tyrosine Kinases / genetics*
  • RNA, Messenger / analysis
  • Tropomyosin / genetics*


  • RNA, Messenger
  • Tropomyosin
  • Poly A
  • DNA
  • Protein-Tyrosine Kinases

Associated data

  • GENBANK/X03541