Excitatory amino acid receptors in hippocampal neurons: kainate fails to desensitize them

Neurosci Lett. 1986 Jan 30;63(3):225-30. doi: 10.1016/0304-3940(86)90360-5.


The excitatory responses to L-glutamate (L-Glu), quisqualate (QA) and kainate (KA) have been investigated in isolated pyramidal cells from rat hippocampus using intracellular perfusion and concentration clamp techniques. The responses to L-Glu and QA demonstrated rapid desensitization and complete cross-desensitization, while KA produced a non-desensitizing response. The activation of KA response was determined by the level of desensitization induced by L-Glu or QA pretreatment. It is concluded that QA, KA and L-Glu activate the same excitatory receptors with apparent Kd values of 9.3 X 10(-5) M, 5.0 X 10(-4) M and 1.1 X 10(-3) M, respectively.

MeSH terms

  • Animals
  • Glutamates / pharmacology
  • Glutamic Acid
  • Hippocampus / cytology
  • Hippocampus / metabolism*
  • Kainic Acid / pharmacology*
  • Neurons / metabolism*
  • Oxadiazoles / pharmacology
  • Quisqualic Acid
  • Rats
  • Receptors, Amino Acid
  • Receptors, Cell Surface / drug effects*


  • Glutamates
  • Oxadiazoles
  • Receptors, Amino Acid
  • Receptors, Cell Surface
  • Glutamic Acid
  • Quisqualic Acid
  • Kainic Acid