Abstract
There is a long list of important RNA-binding proteins (RBP) involved in different steps of gene expression through posttranscriptional modifications: pre-mRNA splicing, mRNA stabilization, polyadenylation, mRNA export from nucleus to the cytoplasm, and translation. The critical role of RNA-protein interaction necessitates a continuous identification of proteins involved in this process. Here we describe the identification of Poly-ADP-Ribose Polymerase 1 (PARP1) as an RNA binding protein involved in RNA splicing.
Keywords:
Chromatin; PAR-CliP; PARP1; RNA-binding proteins; Splicing; mRNA.
MeSH terms
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Adenosine Diphosphate Ribose / metabolism
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Animals
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Chromatin / metabolism
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Gene Expression Regulation / genetics
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Gene Expression Regulation / physiology
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Humans
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Poly (ADP-Ribose) Polymerase-1 / genetics
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Poly (ADP-Ribose) Polymerase-1 / metabolism*
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Protein Processing, Post-Translational / genetics
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Protein Processing, Post-Translational / physiology
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RNA Splicing / genetics
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RNA Splicing / physiology
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism
Substances
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Chromatin
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RNA, Messenger
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RNA-Binding Proteins
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Adenosine Diphosphate Ribose
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Poly (ADP-Ribose) Polymerase-1