Lipid Droplets Guard Mitochondria during Autophagy

Dev Cell. 2017 Jul 10;42(1):1-2. doi: 10.1016/j.devcel.2017.06.018.

Abstract

In this issue of Developmental Cell, Nguyen et al. (2017) show that lipid droplets serve a dual purpose during starvation. First, they act as an energy source by supplying fatty acids for mitochondrial β oxidation. Second, they sequester toxic lipids that arise during autophagic degradation of membranous organelles, thereby protecting mitochondria.

Publication types

  • Comment

MeSH terms

  • Autophagy*
  • Fatty Acids
  • Lipid Droplets*
  • Lipids
  • Mitochondria

Substances

  • Fatty Acids
  • Lipids