Blue diode laser versus traditional infrared diode laser and quantic molecular resonance scalpel: clinical and histological findings after excisional biopsy of benign oral lesions

J Biomed Opt. 2017 Dec 1;22(12):121602. doi: 10.1117/1.JBO.22.12.121602.


This study aims to compare the use of the innovative blue diode laser (BLUE group) with two traditional surgical techniques: the infrared diode laser (IR group) and the quantic molecular resonance scalpel (QMR group) in the excision of benign oral lesions. Ninety-three patients underwent surgical excision of a benign oral lesion and were followed up for 30 days for pain (0 to 10 visual analogue scale), bleeding, and painkillers’ assumption (yes/no). A blind pathologist evaluated the thermal damage along the cutting margin. Although referred pain was lowest in the BLUE group from day 7 on (p<0.05), all patients referred minimum discomfort after surgery. The BLUE group reported minimum bleeding and necessity of sutures (p<0.000). The QMR group showed the highest bleeding during surgery (p<0.000), while after 14 and 30 days no patient bled. Most of the patients in all groups did not need painkillers. The lowest thermal damage (p<0.000) was found in the BLUE group (71.3±51.8???m), whereas the IR group proved the highest (186.8±82.7???m) compared both with the BLUE and QMR (111.4±55.4???m) groups. All the techniques allowed correct histological sampling. All the experimented techniques offer interesting advantages, although the blue laser minimizes risk of bleeding with limited thermal damage.

MeSH terms

  • Biopsy / instrumentation*
  • Humans
  • Infrared Rays
  • Laser Therapy / adverse effects
  • Laser Therapy / standards*
  • Lasers, Semiconductor*
  • Mouth Diseases / surgery*
  • Pain Measurement