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Review
. 2017 Oct;59(9-10):435-444.
doi: 10.1007/s12033-017-0024-9.

Genetically Modified Pigs as Organ Donors for Xenotransplantation

Magdalena Hryhorowicz  1 , Joanna Zeyland  2 , Ryszard Słomski  2   3 , Daniel Lipiński  2
Affiliations
Review

Genetically Modified Pigs as Organ Donors for Xenotransplantation

Magdalena Hryhorowicz et al. Mol Biotechnol. 2017 Oct.

Abstract

The growing shortage of available organs is a major problem in transplantology. Thus, new and alternative sources of organs need to be found. One promising solution could be xenotransplantation, i.e., the use of animal cells, tissues and organs. The domestic pig is the optimum donor for such transplants. However, xenogeneic transplantation from pigs to humans involves high immune incompatibility and a complex rejection process. The rapid development of genetic engineering techniques enables genome modifications in pigs that reduce the cross-species immune barrier.

Keywords: Genetic engineering; Genetically modified pigs; Genome modifications; Transgenic pigs; Xenotransplantation.

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References

    1. Cooper DK, Gollackner B, Sachs DH. Will the pig solve the transplantation backlog? Annual Review of Medicine. 2002;53:133–147. doi: 10.1146/annurev.med.53.082901.103900. - DOI - PubMed
    1. Gaj T, Gersbach CA, Barbas CF., 3rd ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends in Biotechnology. 2013;31(7):397–405. doi: 10.1016/j.tibtech.2013.04.004. - DOI - PMC - PubMed
    1. Platt JL, Fischel RJ, Matas AJ, Reif SA, Bolman RM, Bach FH. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation. 1991;52:214–220. doi: 10.1097/00007890-199108000-00006. - DOI - PubMed
    1. Lai L, Kolber-Simonds D, Park KW, Cheong HT, Greenstein JL, Im GS, et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science. 2002;295:1089–1092. doi: 10.1126/science.1068228. - DOI - PubMed
    1. Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen SH, et al. Production of alpha 1,3-galacto-syltransferase-deficient pigs. Science. 2003;299:411–414. doi: 10.1126/science.1078942. - DOI - PMC - PubMed