Mathematical Simulation of Transport Kinetics of Tumor-Imaging Radiopharmaceutical 99mTc-MIBI

Comput Math Methods Med. 2017:2017:2414878. doi: 10.1155/2017/2414878. Epub 2017 Jun 15.

Abstract

The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical 99mTc-MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be easily tested by the concentration data of the radioactive pharmaceuticals in the blood measured at early time point and late time point of the scanning, and the obtained data can be used for determination of the washout rate coefficient which is one of the existing oncology diagnostics methods.

MeSH terms

  • Computer Simulation*
  • Humans
  • Kinetics
  • Models, Theoretical*
  • Radionuclide Imaging
  • Radiopharmaceuticals / metabolism
  • Technetium Tc 99m Sestamibi / metabolism*

Substances

  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi