Sleep-disordered breathing in patients with neuromuscular disease

Sleep Breath. 2018 May;22(2):277-286. doi: 10.1007/s11325-017-1538-x. Epub 2017 Jul 12.


Sleep-disordered breathing (SDB) is relatively common in general population as well as in patients with neuromuscular disease. SDB comprises a wide spectrum of disorders varying from simple snoring to complete closure of the upper airway as seen in obstructive sleep apnoea (OSA). It includes also other disorders like prolonged hypoxemia, hypoventilation, and central sleep apnoea (CSA). Neuromuscular diseases (NMD) form a group of disorders that can cause significant reduction in the quality and span of life. The involvement of respiratory system in the context of these disorders is the most serious complication, and it is considered as the leading cause of death in those patients. NMD can affect ventilation, cough, swallowing, and phonation. The involvement of respiratory muscles makes NMD patients vulnerable to sleep-disordered breathing with a significant prevalence of SDB among such patients.

Keywords: Hypoventilation; Neuromuscular diseases; Noninvasive ventilation; Sleep-disordered breathing.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypoventilation / complications
  • Hypoventilation / physiopathology
  • Neuromuscular Diseases / complications*
  • Neuromuscular Diseases / physiopathology*
  • Respiratory Muscles / physiology
  • Sleep Apnea Syndromes / complications*
  • Sleep Apnea Syndromes / physiopathology*
  • Sleep Apnea, Central / complications
  • Sleep Apnea, Central / physiopathology
  • Sleep Apnea, Obstructive / complications
  • Sleep Apnea, Obstructive / physiopathology