Epidemiology of human infections with highly pathogenic avian influenza A(H7N9) virus in Guangdong, 2016 to 2017

doi:10.2807/1560-7917.ES.2017.22.27.30568

. 2017 Jul 6;22(27):30568.

doi: 10.2807/1560-7917.ES.2017.22.27.30568.

Epidemiology of human infections with highly pathogenic avian influenza A(H7N9) virus in Guangdong, 2016 to 2017

Min Kang^{1

2}, Eric H Y Lau^{2

3}, Wenda Guan^{2

4}, Yuwei Yang¹, Tie Song¹, Benjamin J Cowling³, Jie Wu¹, Malik Peiris^{4

5}, Jianfeng He¹, Chris Ka Pun Mok^{4

5}

Affiliations

¹ Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, PR China.
² MK, EYL and WG contributed equally to this work.
³ WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, PR China.
⁴ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
⁵ HKU-Pasteur Research Pole, School of Public Health, HKU Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, PR China.

PMID: 28703705
PMCID: PMC5508330
DOI: 10.2807/1560-7917.ES.2017.22.27.30568

Epidemiology of human infections with highly pathogenic avian influenza A(H7N9) virus in Guangdong, 2016 to 2017

Min Kang et al. Euro Surveill. 2017.

. 2017 Jul 6;22(27):30568.

doi: 10.2807/1560-7917.ES.2017.22.27.30568.

Authors

Min Kang^{1

2}, Eric H Y Lau^{2

3}, Wenda Guan^{2

4}, Yuwei Yang¹, Tie Song¹, Benjamin J Cowling³, Jie Wu¹, Malik Peiris^{4

5}, Jianfeng He¹, Chris Ka Pun Mok^{4

5}

Affiliations

¹ Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, PR China.
² MK, EYL and WG contributed equally to this work.
³ WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, PR China.
⁴ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
⁵ HKU-Pasteur Research Pole, School of Public Health, HKU Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, PR China.

PMID: 28703705
PMCID: PMC5508330
DOI: 10.2807/1560-7917.ES.2017.22.27.30568

Abstract

We describe the epidemiology of highly pathogenic avian influenza (HPAI) A(H7N9) based on poultry market environmental surveillance and laboratory-confirmed human cases (n = 9) in Guangdong, China. We also compare the epidemiology between human cases of high- and low-pathogenic avian influenza A(H7N9) (n = 51) in Guangdong. Case fatality and severity were similar. Touching sick or dead poultry was the most important risk factor for HPAI A(H7N9) infections and should be highlighted for the control of future influenza A(H7N9) epidemics.

Keywords: Guangdong; H7N9; HPAI; Influenza.

This article is copyright of The Authors, 2017.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

**Figure**
Epidemic curves for HPAI and LPAI A(H7N9) human cases, Guangdong province, 1 November 2016–31 March 2017 (n = 60)

See this image and copyright information in PMC

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References

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1. Yu H, Cowling BJ, Feng L, Lau EHY, Liao Q, Tsang TK, et al. Human infection with avian influenza A H7N9 virus: an assessment of clinical severity. Lancet. 2013;382(9887):138-45. 10.1016/S0140-6736(13)61207-6 - DOI - PMC - PubMed
1. Chen Z, Liu H, Lu J, Luo L, Li K, Liu Y, et al. Asymptomatic, mild, and severe influenza A(H7N9) virus infection in humans, Guangzhou, China. Emerg Infect Dis. 2014;20(9):1535-40. 10.3201/eid2009.140424 - DOI - PMC - PubMed
1. Wu J, Lau EHY, Xing Q, Zou L, Zhang H, Yen HL, et al. Seasonality of avian influenza A(H7N9) activity and risk of human A(H7N9) infections from live poultry markets. J Infect. 2015;71(6):690-3. 10.1016/j.jinf.2015.08.007 - DOI - PMC - PubMed
1. Wang X, Jiang H, Wu P, Uyeki TM, Feng L, Lai S, et al. Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013-17: an epidemiological study of laboratory-confirmed case series. Lancet Infect Dis. 2017;S1473-3099(17)30323-7. - PMC - PubMed

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[1] World Health Organization (WHO). Influenza at the human-animal interface: Summary and assessment, 17 May 2017 to 15 June 2017. Geneva: WHO; 2017. Available from: http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IR...

[2] World Health Organization (WHO). Influenza at the human-animal interface: Summary and assessment, 17 May 2017 to 15 June 2017. Geneva: WHO; 2017. Available from: http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IR...

[3] Yu H, Cowling BJ, Feng L, Lau EHY, Liao Q, Tsang TK, et al. Human infection with avian influenza A H7N9 virus: an assessment of clinical severity. Lancet. 2013;382(9887):138-45. 10.1016/S0140-6736(13)61207-6 - DOI - PMC - PubMed

[4] Yu H, Cowling BJ, Feng L, Lau EHY, Liao Q, Tsang TK, et al. Human infection with avian influenza A H7N9 virus: an assessment of clinical severity. Lancet. 2013;382(9887):138-45. 10.1016/S0140-6736(13)61207-6 - DOI - PMC - PubMed

[5] Chen Z, Liu H, Lu J, Luo L, Li K, Liu Y, et al. Asymptomatic, mild, and severe influenza A(H7N9) virus infection in humans, Guangzhou, China. Emerg Infect Dis. 2014;20(9):1535-40. 10.3201/eid2009.140424 - DOI - PMC - PubMed

[6] Chen Z, Liu H, Lu J, Luo L, Li K, Liu Y, et al. Asymptomatic, mild, and severe influenza A(H7N9) virus infection in humans, Guangzhou, China. Emerg Infect Dis. 2014;20(9):1535-40. 10.3201/eid2009.140424 - DOI - PMC - PubMed

[7] Wu J, Lau EHY, Xing Q, Zou L, Zhang H, Yen HL, et al. Seasonality of avian influenza A(H7N9) activity and risk of human A(H7N9) infections from live poultry markets. J Infect. 2015;71(6):690-3. 10.1016/j.jinf.2015.08.007 - DOI - PMC - PubMed

[8] Wu J, Lau EHY, Xing Q, Zou L, Zhang H, Yen HL, et al. Seasonality of avian influenza A(H7N9) activity and risk of human A(H7N9) infections from live poultry markets. J Infect. 2015;71(6):690-3. 10.1016/j.jinf.2015.08.007 - DOI - PMC - PubMed

[9] Wang X, Jiang H, Wu P, Uyeki TM, Feng L, Lai S, et al. Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013-17: an epidemiological study of laboratory-confirmed case series. Lancet Infect Dis. 2017;S1473-3099(17)30323-7. - PMC - PubMed

[10] Wang X, Jiang H, Wu P, Uyeki TM, Feng L, Lai S, et al. Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013-17: an epidemiological study of laboratory-confirmed case series. Lancet Infect Dis. 2017;S1473-3099(17)30323-7. - PMC - PubMed

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Epidemiology of human infections with highly pathogenic avian influenza A(H7N9) virus in Guangdong, 2016 to 2017

Affiliations

Epidemiology of human infections with highly pathogenic avian influenza A(H7N9) virus in Guangdong, 2016 to 2017

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