Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats

Environ Toxicol Pharmacol. 2017 Sep:54:105-111. doi: 10.1016/j.etap.2017.06.026. Epub 2017 Jul 1.


This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p<0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p<0.05). All parameters showed improvement in groups treated with ferulic acid (p<0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.

Keywords: Cisplatin; Curcumin; Ferulic acid; Kidney.

MeSH terms

  • Animals
  • Blood Urea Nitrogen
  • Cisplatin
  • Coumaric Acids / pharmacology
  • Coumaric Acids / therapeutic use*
  • Curcumin / pharmacology
  • Curcumin / therapeutic use
  • Heme Oxygenase (Decyclizing) / genetics
  • Kidney / drug effects
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney Diseases / chemically induced
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / metabolism
  • Kidney Diseases / pathology
  • Male
  • Malondialdehyde / metabolism
  • Peroxidase / metabolism
  • Protective Agents / pharmacology
  • Protective Agents / therapeutic use*
  • RNA, Messenger / metabolism
  • Rats, Wistar
  • Tyrosine / analogs & derivatives
  • Tyrosine / metabolism


  • Coumaric Acids
  • Protective Agents
  • RNA, Messenger
  • 3-nitrotyrosine
  • Tyrosine
  • Malondialdehyde
  • ferulic acid
  • Peroxidase
  • Heme Oxygenase (Decyclizing)
  • Hmox1 protein, rat
  • Curcumin
  • Cisplatin