Sirtuins in Skin and Skin Cancers

Skin Pharmacol Physiol. 2017;30(4):216-224. doi: 10.1159/000477417. Epub 2017 Jul 14.

Abstract

The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases. Based on the available literature, the sirtuins appear to be important targets in the management of a variety of skin diseases from cosmetic (e.g., skin aging) to fatal conditions (e.g., melanoma).

Keywords: Histone deacetylases; Sirtuins; Skin.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Oxidative Stress
  • Sirtuins / metabolism*
  • Skin Aging / physiology
  • Skin Neoplasms / metabolism*
  • Ultraviolet Rays
  • Wound Healing

Substances

  • Sirtuins