Abstract
Thirteen patients with severe partially reversible chronic obstructive lung disease received long-term treatment with a sustained-release preparation of theophylline and a beta 2-agonist (terbutaline) alone and in combination. Combination therapy induced significantly greater bronchodilation than treatment with terbutaline alone in the recommended dose. In 9 out of 13 patients the peak flows were higher during combination therapy than during theophylline treatment alone, but this did not reach statistical significance. Only mild side effects were observed.
MeSH terms
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Adult
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Aged
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Asthma / drug therapy
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Asthma / physiopathology
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Bronchi / drug effects
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Bronchi / physiopathology
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Bronchodilator Agents / administration & dosage
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Bronchodilator Agents / therapeutic use*
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Drug Synergism
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Drug Therapy, Combination
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Female
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Humans
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Lung Diseases, Obstructive / drug therapy*
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Lung Diseases, Obstructive / physiopathology
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Male
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Middle Aged
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Piperidines / therapeutic use
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Terbutaline / administration & dosage
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Terbutaline / pharmacology
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Terbutaline / therapeutic use*
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Theophylline / administration & dosage
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Theophylline / pharmacology
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Theophylline / therapeutic use
Substances
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Bronchodilator Agents
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Piperidines
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Theophylline
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Terbutaline