Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing

J Biomater Appl. 2017 Sep;32(3):311-320. doi: 10.1177/0885328217719854. Epub 2017 Jul 14.


The search for new therapies and drugs that act as topical agents to relieve pain and control the infectious processes in burns always attracted interest in clinical trials. As an alternative to synthetic drugs, the use of natural extracts is useful in the development of new strategies and formulations for improving the life quality. The aim of this study was to develop a wound dressing using Poly(L-co-D,L lactic acid-co-TMC) (PLDLA-co-TMC) containing aloe vera (AV). This natural plant extract is known for its modulatory effects under healing process. The membrane of PLDLA-co-TMC+aloe vera was prepared at different concentrations of AV (5, 10, 15 and 50%). The FTIR showed no change in the PLDLA-co-TMC spectrum after AV addition, while the swelling test showed changes only in PLDLA-co-TMC+AV at 50%. The wettability measurements showed decrease in the contact angle in all samples after the AV addition in the polymer, while the AV release test showed that PLDLA-co-TMC+50%AV sample has higher AV release rate than the sample with other AV concentrations. The SEM analysis showed that AV was homogeneously distributed at 5% only. Tensile tests demonstrated an increase in the Young's modulus and a reduction in the elongation till rupture of the PLDLA-co-TMC after the addition of AV. Biocompatibility in vitro evaluation with fibroblast cells seeded in the membranes of PLDLA-co-TMC+AV showed that the cells were able to adhere, proliferate and maintain mitochondrial activity in all AV concentrations tested. Due to the known skin medicinal properties attributed to AV and the results here obtained, we suggest that after in vivo trials, the PLDLA-co-TMC+AV should be a promising biomaterial for application as a device for skin curative and healing agent.

Keywords: Bioreabsorbable polymers; L lactic acid-co-trimethylene carbonate); aloe vera; curative; poly (L-co-D; wound healing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Animals
  • Bandages*
  • Biocompatible Materials / chemistry*
  • Cell Line
  • Dioxanes / chemistry*
  • Elastic Modulus
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism
  • Membranes, Artificial
  • Plant Extracts / administration & dosage*
  • Plant Extracts / therapeutic use
  • Polyesters / chemistry*
  • Rats
  • Tensile Strength
  • Wound Healing / drug effects


  • Biocompatible Materials
  • Dioxanes
  • Membranes, Artificial
  • Plant Extracts
  • Polyesters
  • trimethylene carbonate
  • poly(lactide)