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Comment
. 2017 Aug 1;114(31):E6271-E6272.
doi: 10.1073/pnas.1708560114. Epub 2017 Jul 14.

Statistical Reanalysis of Natural Products Reveals Increasing Chemical Diversity

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Statistical Reanalysis of Natural Products Reveals Increasing Chemical Diversity

Michael A Skinnider et al. Proc Natl Acad Sci U S A. .
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Conflict of interest statement

The authors declare no conflict of interest.

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Fig. 1.
Fig. 1.
Statistical reanalysis of natural product structural diversity, 1900–2013. (A) Number of NPs published per year in our in-house database of NP structures. (B) Fraction of structurally novel NPs published per year (Tc < 0.4). (C) Median maximum Tc between newly discovered NPs and all previously known NPs as a function of time. All shaded regions show median absolute deviation. (D) Same as B, with year of NP discovery randomly permuted. Results of 100 bootstraps are shown. (E) Same as C, with year of NP discovery randomly permuted. (F and G) Same as B and C, with NP structures replaced by a random sample of commercially available compounds from ZINC. (H) Ratio of structurally novel NPs published per year to random expectation. (I) Ratio of median maximum Tc between newly discovered NPs and all previously known NPs to random expectation as a function of time.

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