Genetics of Juvenile Idiopathic Arthritis

Aimee O Hersh; Sampath Prahalad

doi:10.1016/j.rdc.2017.04.007

Genetics of Juvenile Idiopathic Arthritis

Rheum Dis Clin North Am. 2017 Aug;43(3):435-448. doi: 10.1016/j.rdc.2017.04.007.

Authors

Aimee O Hersh¹, Sampath Prahalad²

Affiliations

¹ Pediatric Rheumatology, University of Utah School of Medicine, 81 Mario Capecchi Drive, 4th Floor, Salt Lake City, UT 84113, USA.
² Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, 1760 Haygood Drive Northeast, Atlanta, GA 30322, USA; Department of Human Genetics, Children's Healthcare of Atlanta, Emory University School of Medicine, 1760 Haygood Drive Northeast, Atlanta, GA 30322, USA. Electronic address: sprahal@emory.edu.

PMID: 28711144
DOI: 10.1016/j.rdc.2017.04.007

Abstract

Juvenile idiopathic arthritis (JIA) affects approximately 1 in 1000 US children. The cause of JIA is most likely multifactorial and due to an interplay of genetics and environmental factors. This article summarizes the known genetic risk factors for JIA that have been identified, and in some cases replicated, using a variety of methods, including genomewide association and candidate gene association studies. A brief discussion regarding pharmacogenomics and studies to data linking genetics to treatment response and outcomes is included.

Keywords: Association; Genetics; Genomewide; Juvenile idiopathic arthritis.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Arthritis, Juvenile / genetics*
Humans

Grants and funding

K23 AR066064/AR/NIAMS NIH HHS/United States