Clinical management and survival of patients with central nervous system hemangiopericytoma in the National Cancer Database

J Clin Neurosci. 2017 Oct:44:169-174. doi: 10.1016/j.jocn.2017.06.036. Epub 2017 Jul 12.

Abstract

Purpose/objectives: Hemangiopericytomas are rare central nervous system (CNS) tumors. We sought to investigate existing clinical management strategies and overall survival (OS) among patients with hemangiopericytomas of the CNS.

Methods/materials: All patients diagnosed with CNS hemangiopericytoma from 2004 to 2014 in the National Cancer Database were included. Clinical and treatment-related characteristics were analyzed for an association with OS following diagnosis using univariable and multivariable analyses.

Results: Nine-hundred and eighty-one patients were included (0.22% of all CNS tumors). At diagnosis, 22 patients had spinal tumors (2%), 21 patients had multifocal tumors (2%) 28 had disseminated disease (3%), and the remainder were unifocal intracranial tumors. Patients either underwent surgical resection and radiation (48%), surgery alone (37%), radiation alone (6%), or biopsy alone (9%). Of patients with known extent of resection, 53% underwent gross total resection, and, of patients with known radiation modality, 15% received stereotactic radiosurgery. Among the total cohort, 3 and 10year OS was 87% and 59%, respectively. On multivariable analysis, factors associated with inferior OS included age (HR=1.05, p<0.001), WHO grade (p<0.001), multifocal disease (HR=2.59, p=0.04), disseminated disease (HR=2.67, p=0.01), and chemotherapy (HR=2.66, p=0.01). Patients receiving surgery alone or surgery and radiation demonstrated improved OS compared to biopsy alone (HR=0.45, p=0.01 and HR=0.47, p=0.02, respectively). However radiation utilization did not impact OS (p=0.691).

Conclusions: The present data provide large-scale prognostic information from a contemporary cohort of patients with hemangiopericytoma and support an initial attempt at surgical extirpation. The benefits of ionizing radiation are likely limited to improved local control and neurologic function.

Keywords: CNS; Hemangiopericytoma; NCDB; Radiation; Radiosurgery; Surgery; Survival.

MeSH terms

  • Adult
  • Aged
  • Central Nervous System Neoplasms / pathology
  • Female
  • Hemangiopericytoma / radiotherapy*
  • Hemangiopericytoma / surgery
  • Humans
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology*
  • Radiosurgery / adverse effects*
  • Survival Analysis