Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

J Pharm Pharmacol. 1986 Mar;38(3):177-81. doi: 10.1111/j.2042-7158.1986.tb04540.x.


A new model, the dispersion model of hepatic elimination, is applied to the correlation between in-vitro microsomal data and corresponding rat isolated perfused liver data for a number of drugs reported in the literature, whose extraction ratio varies over the range of 0.01 to 0.995. The dispersion model described the data better than either the 'well-stirred' model or the 'parallel-tube' model, two other widely used models of hepatic elimination. The experimental data support the concept that elimination of solutes is affected by is a considerable dispersion on passage through the liver.

MeSH terms

  • Animals
  • In Vitro Techniques
  • Kinetics
  • Liver / metabolism*
  • Metabolic Clearance Rate
  • Microsomes, Liver / enzymology*
  • Models, Biological
  • Perfusion
  • Rats