Biliary bile acids in hepatobiliary injury - What is the link?

J Hepatol. 2017 Sep;67(3):619-631. doi: 10.1016/j.jhep.2017.04.026. Epub 2017 Jul 14.

Abstract

The main trigger for liver injury in acquired cholestatic liver disease remains unclear. However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in deciphering the pathomechanisms of inborn cholestatic liver diseases, decoding mechanisms of BA-induced cell death, and generating modern BA-derived drugs has improved the understanding of the regulation of BA synthesis and transport. Now is the appropriate time to reassess current knowledge about the specific role of BAs in hepatobiliary injury.

Keywords: Bile canaliculus; Bile ducts; Bile secretion; Cholangiopathies; Cholangitis; Primary biliary cholangitis; Primary sclerosing cholangitis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / physiology
  • ATP Binding Cassette Transporter, Subfamily B, Member 11 / physiology
  • ATP-Binding Cassette Sub-Family B Member 4
  • Animals
  • Apoptosis
  • Autophagy
  • Bile Acids and Salts / physiology*
  • Carrier Proteins / physiology
  • Cholestasis / etiology*
  • Humans
  • Liver / pathology
  • Liver Cirrhosis / etiology
  • Membrane Glycoproteins / physiology
  • Mice

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 11
  • Bile Acids and Salts
  • Carrier Proteins
  • Membrane Glycoproteins
  • bile acid binding proteins