[Endometriosis and miscarriage: Systematic review]

Gynecol Obstet Fertil Senol. Jul-Aug 2017;45(7-8):393-399. doi: 10.1016/j.gofs.2017.06.003. Epub 2017 Jul 13.
[Article in French]


Objectives: In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriage. The aim of this study is to evaluate the association between endometriosis and miscarriage in spontaneous pregnancy.

Methods: We searched the Cochrane Library, Medline of eligible studies from inception to December 2016, without any restriction. We selected studies that compared endometriosis-affected pregnant women to disease-free pregnant women. To ensure the quality of the methodology, the PRISMA criteria have been met at all stages of the development of this meta-analysis. The primary adverse pregnancy outcomes studied was miscarriage. Three reviewers independently extracted the studies' characteristics and outcome data.

Results: Of 225 identified abstracts, 4 primary studies met our inclusion criteria by comparing spontaneous pregnant patients with endometriosis to disease-free women. Miscarriage rate was higher in the endometriosis group (OR 1.77 [CI 95% 1.13-2.78]).

Conclusion: In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriages (almost 80% increased risk). Further prospective studies are needed to confirm these results in order to establish the exact impact of endometriosis on spontaneous pregnancy course.

Keywords: Avortement spontané; Endometriosis; Endométriose; Fausse couche spontanée; Fetal loss; Grossesse spontanée; Miscarriage; Perte fœtale; Spontaneous abortion; Spontaneous pregnancy.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Abortion, Spontaneous / etiology*
  • Endometriosis / complications*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications*
  • Pregnancy Outcome
  • Risk Factors