A community proposal to integrate proteomics activities in ELIXIR

F1000Res. 2017 Jun 13:6:ELIXIR-875. doi: 10.12688/f1000research.11751.1. eCollection 2017.


Computational approaches have been major drivers behind the progress of proteomics in recent years. The aim of this white paper is to provide a framework for integrating computational proteomics into ELIXIR in the near future, and thus to broaden the portfolio of omics technologies supported by this European distributed infrastructure. This white paper is the direct result of a strategy meeting on 'The Future of Proteomics in ELIXIR' that took place in March 2017 in Tübingen (Germany), and involved representatives of eleven ELIXIR nodes. These discussions led to a list of priority areas in computational proteomics that would complement existing activities and close gaps in the portfolio of tools and services offered by ELIXIR so far. We provide some suggestions on how these activities could be integrated into ELIXIR's existing platforms, and how it could lead to a new ELIXIR use case in proteomics. We also highlight connections to the related field of metabolomics, where similar activities are ongoing. This white paper could thus serve as a starting point for the integration of computational proteomics into ELIXIR. Over the next few months we will be working closely with all stakeholders involved, and in particular with other representatives of the proteomics community, to further refine this paper.

Keywords: bioinformatics infrastructure; computational proteomics; data standards; databases; mass spectrometry; multi-omics approaches.; proteomics; training.

Grants and funding

The meeting was funded by funds provided by the ELIXIR Central Hub (supported by EU H2020 Research Infrastructures). This activity is included in the ELIXIR Implementation Project entitled ‘Mining the Proteome: Enabling Automated Processing and Analysis of Large-Scale Proteomics Data’.