Microglia in steady state

J Clin Invest. 2017 Sep 1;127(9):3201-3209. doi: 10.1172/JCI90602. Epub 2017 Jul 17.


Microglial cells are the resident tissue macrophages of the CNS and are widely recognized for their immune surveillance of the healthy CNS. In addition to this well-accepted function, recent findings point to major roles for microglia in instructing and regulating the proper function of the neuronal networks in the adult CNS, but these cells are also involved in creating neuronal networks by orchestrating construction of the whole network during development. In this Review, we highlight recent findings about the steady-state functions of microglial cells, the factors that are important for physiological microglial function, and how microglia help to maintain tissue homeostasis in the CNS.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / embryology
  • Brain / physiology
  • Central Nervous System / cytology
  • Central Nervous System / physiology*
  • Homeostasis
  • Humans
  • Immune System
  • Mice
  • Microglia / physiology*
  • Nerve Net
  • Neurons / physiology