Designation of Alpha-Phenylacetoacetonitrile (APAAN), a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine, as a List I Chemical. Final rule

Fed Regist. 2017 Jul 14;82(134):32457-61.


The Drug Enforcement Administration (DEA) is finalizing the designation of the chemical alpha-phenylacetoacetonitrile (APAAN) and its salts, optical isomers, and salts of optical isomers, as a list I chemical under the Controlled Substances Act (CSA). The DEA proposed control of APAAN, due to its use in clandestine laboratories to illicitly manufacture the schedule II controlled substances phenylacetone (also known as phenyl-2-propanone or P2P), methamphetamine, and amphetamine. This rulemaking finalizes, without change, the control of APAAN as a list I chemical. This action does not establish a threshold for domestic and international transactions of APAAN. As such, all transactions involving APAAN, regardless of size, shall be regulated. In addition, chemical mixtures containing APAAN are not exempt from regulatory requirements at any concentration. Therefore, all transactions of chemical mixtures containing any quantity of APAAN shall be regulated pursuant to the CSA. However, manufacturers may submit an application for exemption for those mixtures that do not qualify for automatic exemption.

MeSH terms

  • Acetone / analysis
  • Acetone / supply & distribution
  • Acetonitriles / analysis
  • Acetonitriles / classification*
  • Amphetamine / analysis
  • Drug and Narcotic Control / legislation & jurisprudence*
  • Humans
  • Illicit Drugs
  • Methamphetamine / analysis
  • United States


  • Acetonitriles
  • Illicit Drugs
  • Acetone
  • Methamphetamine
  • Amphetamine