Reduced Brain Volume and Impaired Memory in Betaine Homocysteine S-methyltransferase Knockout Mice

Appl Physiol Nutr Metab. 2017 Nov;42(11):1228-1231. doi: 10.1139/apnm-2017-0182. Epub 2017 Jul 17.

Abstract

Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.

Keywords: IRM; MRI; Morris water maze; Y-maze; betaine homocysteine S-methyltransferase; bétaïne homocystéine S-méthyltransférase; homocysteine; homocystéine; labyrinthe aquatique de Morris; labyrinthe en Y; memory; mémoire.

MeSH terms

  • Animals
  • Betaine-Homocysteine S-Methyltransferase / genetics*
  • Brain / anatomy & histology*
  • Brain / diagnostic imaging
  • Brain / physiology*
  • Gene Deletion
  • Homocysteine / blood
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders
  • Memory*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Organ Size

Substances

  • Homocysteine
  • Betaine-Homocysteine S-Methyltransferase
  • Bhmt protein, mouse