Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct;58:68-76.
doi: 10.1016/j.neurobiolaging.2017.05.019. Epub 2017 Jun 2.

Cognitive Decline and Brain Amyloid-β Accumulation Across 3 Years in Adults With Down Syndrome

Affiliations
Free PMC article

Cognitive Decline and Brain Amyloid-β Accumulation Across 3 Years in Adults With Down Syndrome

Sigan L Hartley et al. Neurobiol Aging. .
Free PMC article

Abstract

Adults with Down syndrome (DS) have a high incidence of Alzheimer's disease (AD), providing a unique opportunity to explore the early, preclinical stages of AD neuropathology. We examined change in brain amyloid-β accumulation via the positron emission tomography tracer [11C] Pittsburgh compound B (PiB) across 2 data collection cycles, spaced 3 years apart, and decline in cognitive functioning in 58 adults with DS without clinical AD. PiB retention increased in the anterior cingulate gyrus, precuneus cortex, parietal cortex, and anterior ventral striatum. Across the 2 cycles, 14 (27.5%) participants were consistently PiB+, 31 (60.8%) were consistently PiB-, and 6 (11.7%) converted from PiB- at cycle 1 to PiB+ at cycle 2. Increased global amyloid-β was related to decline in verbal episodic memory, visual episodic memory, executive functioning, and fine motor processing speed. Participants who were consistently PiB+ demonstrated worsening of episodic memory, whereas participants who were consistently PiB- evidenced stable or improved performance. Amyloid-β accumulation may be a contributor to or biomarker of declining cognitive functioning in preclinical AD in DS.

Keywords: Alzheimer's disease; Amyloid-β; Dementia; Down syndrome; Mild cognitive impairment; PiB.

Figures

Figure 1
Figure 1
Change from Cycle 1 to Cycle 2 in Free and Cued Recall Total score by PiB Categorization group. The one participant who had a floor level (i.e., lowest possible score) score at Cycle 1 was removed.
Figure 2
Figure 2
Change from Cycle 1 to Cycle 2 in Cued Intrusions Total score by PiB Categorization group.

Similar articles

See all similar articles

Cited by 11 articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

Feedback