Cancer recurrence monitoring using hyperpolarized [1- 13 C]pyruvate metabolic imaging in murine breast cancer model

Magn Reson Imaging. 2017 Nov;43:105-109. doi: 10.1016/j.mri.2017.07.014. Epub 2017 Jul 15.

Abstract

The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial 1H MRI and hyperpolarized [1-13C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion. Moreover, cancer recurrences occurring at the tumor sites independently of MYC expression were observed to accompany markedly increased lactate production.

Keywords: Breast cancer; Cancer recurrence; Hyperpolarized (13)C MRI; Metabolic imaging.

MeSH terms

  • Animals
  • Carbon Isotopes
  • Female
  • Glycolysis
  • Humans
  • Lactic Acid / metabolism*
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy*
  • Mammary Neoplasms, Animal / diagnostic imaging*
  • Mammary Neoplasms, Animal / metabolism
  • Mice
  • Mice, Transgenic
  • Neoplasm Recurrence, Local
  • Neoplasm Transplantation
  • Proto-Oncogene Proteins c-myc / genetics
  • Pyruvic Acid / metabolism*
  • Tumor Burden

Substances

  • Carbon Isotopes
  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • Lactic Acid
  • Pyruvic Acid