Addison's Disease Caused by Tuberculosis with Atypical Hyperpigmentation and Active Pulmonary Tuberculosis

Intern Med. 2017;56(14):1843-1847. doi: 10.2169/internalmedicine.56.7976. Epub 2017 Jul 15.


We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and the occurrence of new freckles, that was diagnosed in the presence of active pulmonary tuberculosis. The clinical condition of the patient was markedly ameliorated by the administration of hydrocortisone and anti-tuberculosis agents. When exacerbation of the pigmentation of the freckles and/or the occurrence of new freckles are noted, Addison's disease should be considered as part of the differential diagnosis. In addition, the presence of active tuberculosis needs to be assumed whenever we treat patients with Addison's disease caused by tuberculosis, despite its rarity.

Keywords: Addison's disease; active tuberculosis; adrenal insufficiency; freckles; hyperpigmentation; pulmonary tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Addison Disease / diagnosis
  • Addison Disease / etiology*
  • Diagnosis, Differential
  • Humans
  • Hyperpigmentation / physiopathology*
  • Male
  • Middle Aged
  • Tuberculosis, Pulmonary / complications*
  • Tuberculosis, Pulmonary / physiopathology*