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Review
. 2017 Jul 13:22:11.
doi: 10.1186/s11658-017-0042-4. eCollection 2017.

Cells of human breast milk

Malgorzata Witkowska-Zimny  1 , Ewa Kaminska-El-Hassan  1
Affiliations
Free PMC article
Review

Cells of human breast milk

Malgorzata Witkowska-Zimny et al. Cell Mol Biol Lett. .
Free PMC article

Abstract

Human milk is a complex fluid that has developed to satisfy the nutritional requirements of infants. In addition to proteins, lipids, carbohydrates and other biologically active components, breast milk contains a diverse microbiome that is presumed to colonize the infant gastrointestinal tract and a heterogeneous population of cells with unclear physiological roles and health implications. Noteworthy cellular components of breast milk include progenitor/stem cells. This review summarizes the current state of knowledge of breast milk cells, including leukocytes, epithelial cells, stem cells and potentially probiotic bacteria.

Keywords: Human breast milk; Leukocytes; Microbiome; Probiotic bacteria; Stem cells.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Cells present in human breast milk
Fig. 2
Fig. 2
Morphology of the breast milk-derived cells. a Heterogeneous cell population including leukocytes. b Mammosphere created by hBSCs on Matrigel (on day 8 after isolation). c Subpopulation of lactocytes and myoepithelial cells on day 2 after isolation, culture in vitro on tissue culture plates
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References

    1. Victora CG, Bahl R, Barros AJD, França GWA, Horton S, et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet. 2016;387:475–490. doi: 10.1016/S0140-6736(15)01024-7. - DOI - PubMed
    1. Lawerence RA, Lawerence RM. Breastfeeding. A Guide for the Medical Profession. 8th ed. Canada: Elsevier; 2016.
    1. Merhav HJ, Wright HI, Mieles LA, Van Thiel DH. Treatment of IgA deficiency in liver transplant recipients with human breast milk. Transpl Int. 1995;8(4):327–329. doi: 10.1111/j.1432-2277.1995.tb01530.x. - DOI - PubMed
    1. Cristofalo EA, Schanler RJ, Blanco CL, Sullivan S, Trawoeger R, et al. Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J Pediatr. 2013;163(6):1592–1595. doi: 10.1016/j.jpeds.2013.07.011. - DOI - PubMed
    1. Hassiotou F, Hepworth AR, Williams TM, Twigger A-J, Perrella S, et al. Breastmilk cell and fat contents respond similarly to removal of Breastmilk by the infant. PLoS One. 2013;8(11):e78232. doi: 10.1371/journal.pone.0078232. - DOI - PMC - PubMed