Association Between Vancomycin Blood Brain Barrier Penetration and Clinical Response in Postsurgical Meningitis

J Pharm Pharm Sci. 2017;20(0):161-167. doi: 10.18433/J3493F.


Purpose: This study investigated the association between vancomycin blood brain barrier penetration and clinical response in patients with postsurgical meningitis.

Methods: Adult patients with postsurgical meningitis were recruited. Eligible patients received vancomycin 500 mg every 6 h for at least 5 days. On day 3 or 4, cerebrospinal fluid (CSF) and simultaneous serum samples were obtained to determine CSF minimum concentrations (Cmin), serum Cmin and CSF to serum Cmin ratio.

Results: Twenty-two patients (14 men and 8 women; mean age of 52.6± 12.1 years) were recruited. The vancomycin Cmin was 3.63 ± 1.64 mg/L in CSF and 13.38 ± 5.36 mg/L in serum, with the CSF to serum Cmin ratio of 0.291 ± 0.118. The Cmin in serum and in CSF showed a significant correlation (p=0.005, r =0.575). The vancomycin CSF Cmin had a significant correlation with the decline of white blood cell counts (WBCs) in CSF (p=0.003, r =0.609). CSF Cmin, serum Cmin and CSF to serum Cmin ratio all showed no significant correlation with clinical response (p=0.335, 0.100, 0.679, respectively).

Conclusions: There was a positive correlation between serum Cmin and CSF Cmin. However, only CSF Cmin is positively correlated with WBCs improvement in CSF. All other parameters such as serum Cmin, CSF Cmin and CSF to serum Cmin ratio had no correlation with clinical response. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / pharmacology*
  • Blood-Brain Barrier / drug effects*
  • Female
  • Humans
  • Male
  • Meningitis / drug therapy*
  • Meningitis / surgery
  • Middle Aged
  • Prospective Studies
  • Vancomycin / administration & dosage
  • Vancomycin / blood
  • Vancomycin / pharmacology*


  • Anti-Bacterial Agents
  • Vancomycin