Cerebral hypoperfusion is not associated with an increase in amyloid β pathology in middle-aged or elderly people

Alzheimers Dement. 2018 Jan;14(1):54-61. doi: 10.1016/j.jalz.2017.06.2265. Epub 2017 Jul 15.


Introduction: It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans.

Methods: Cerebral blood flow and amyloid β (18F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of precerebral arteries resulting in chronic and uneven hypoperfusion. A subset of patients underwent tau (18F-AV-1451) positron emission tomography.

Results: The blood flow was significantly reduced on the affected side of the brain in patients with unilateral occlusion of the internal carotid artery or stenosis of the middle cerebral artery. However, the cortical uptake of 18F-Flutemetamol or 18F-AV-1451 was not altered.

Discussion: Our results suggest that longstanding cerebral hypoperfusion in humans does not result in accumulation of amyloid β fibrils or tau aggregates.

Keywords: Alzheimer's disease; Cerebral hypoperfusion; Pathogenesis; Tau; amyloid β.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnostic imaging
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / metabolism*
  • Aniline Compounds / pharmacokinetics
  • Benzothiazoles / pharmacokinetics
  • Brain / diagnostic imaging*
  • Brain / drug effects
  • Carbolines / pharmacokinetics
  • Cerebrovascular Circulation / drug effects
  • Cerebrovascular Circulation / physiology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Sweden / epidemiology
  • Tomography, X-Ray Computed


  • Amyloid beta-Peptides
  • Aniline Compounds
  • Benzothiazoles
  • Carbolines
  • flutemetamol
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole