Optic neuritis in pregnancy after Tdap vaccination: Report of two cases

Clin Neurol Neurosurg. 2017 Sep;160:116-118. doi: 10.1016/j.clineuro.2017.07.002. Epub 2017 Jul 11.


Two pregnant women developed one-eye blurring vision within three weeks after Tdap vaccination. Neurophtalmologic and MR examination confirmed an unilateral optic neuritis without evidence of underlying disease. Both patients had a full recovery, one after intravenous metilprednisolone. This is the first report of optic neuritis related with Tdap vaccination in pregnancy.

Keywords: Pertussis vaccination; Postvaccination optic neuritis; Tdap vaccination.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects*
  • Female
  • Humans
  • Optic Neuritis / etiology*
  • Pregnancy
  • Pregnancy Complications / etiology*
  • Pregnancy Complications / immunology


  • Diphtheria-Tetanus-acellular Pertussis Vaccines