The potential of phage therapy in cystic fibrosis: Essential human-bacterial-phage interactions and delivery considerations for use in Pseudomonas aeruginosa-infected airways

J Cyst Fibros. 2017 Nov;16(6):663-670. doi: 10.1016/j.jcf.2017.06.012. Epub 2017 Jul 15.

Abstract

As antimicrobial-resistant microbes become increasingly common and a significant global issue, novel approaches to treating these infections particularly in those at high risk are required. This is evident in people with cystic fibrosis (CF), who suffer from chronic airway infection caused by antibiotic resistant bacteria, typically Pseudomonas aeruginosa. One option is bacteriophage (phage) therapy, which utilises the natural predation of phage viruses upon their host bacteria. This review summarises the essential and unique aspects of the phage-microbe-human lung interactions in CF that must be addressed to successfully develop and deliver phage to CF airways. The current evidence regarding phage biology, phage-bacterial interactions, potential airway immune responses to phages, previous use of phages in humans and method of phage delivery to the lung are also summarised.

Keywords: Antimicrobial; Bacteriophage; Cystic fibrosis; Infection; Phage therapy; Pseudomonas aeruginosa.

Publication types

  • Review

MeSH terms

  • Cystic Fibrosis / complications*
  • Drug Delivery Systems*
  • Humans
  • Phage Therapy / methods*
  • Pseudomonas Infections* / etiology
  • Pseudomonas Infections* / therapy
  • Pseudomonas aeruginosa / physiology
  • Respiratory Tract Infections* / microbiology
  • Respiratory Tract Infections* / therapy