11 C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia

Clin Interv Aging. 2017 Jun 29;12:1041-1048. doi: 10.2147/CIA.S132884. eCollection 2017.

Abstract

Purpose: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent.

Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone 11C-labeled Pittsburgh compound B-positron emission tomography imaging.

Results: Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate).

Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.

Keywords: Alzheimer’s disease; Pittsburgh compound B; amyloid; amyloid PET; basal ganglia; early-onset Alzheimer’s disease.

MeSH terms

  • Age of Onset*
  • Aged
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / genetics
  • Aniline Compounds
  • Apolipoproteins E / genetics
  • Basal Ganglia / metabolism*
  • Benzothiazoles
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Positron-Emission Tomography / methods
  • Presenilin-1 / genetics
  • Presenilin-2 / genetics
  • Thiazoles

Substances

  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • APP protein, human
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Aniline Compounds
  • ApoE protein, human
  • Apolipoproteins E
  • Benzothiazoles
  • PSEN1 protein, human
  • PSEN2 protein, human
  • Presenilin-1
  • Presenilin-2
  • Thiazoles