Persistent papilloma treated with cryotherapy in three dogs

Vet Dermatol. 2017 Dec;28(6):625-e154. doi: 10.1111/vde.12469. Epub 2017 Jul 18.


Background: Canine papillomaviruses can affect the mucous membranes and skin of young, old and immunocompromised dogs. Most lesions regress spontaneously over a four to eight week interval; however, in some cases the lesions may persist or progress. Cryotherapy is used as a treatment for papillomavirus induced lesions in veterinary practice but there is limited published evidence regarding its use.

Objectives: To describe the history, lesions and treatment outcomes of three dogs with persistent viral papillomas treated with cryotherapy.

Animals: Three client owned dogs.

Methods: Canine viral papilloma lesions were treated with five to six freeze-thaw cycles using liquid nitrogen cryotherapy.

Results: All lesions in each case resolved with cryotherapy treatment. Two cases required one treatment and one case required two treatment courses.

Conclusions and clinical importance: The apparent resolution of these papilloma lesions with cryotherapy suggests that this may be a useful treatment intervention for persistent canine papilloma lesions. Spontaneous resolution may still have taken place; consequently, large scale clinical trials are required to demonstrate unequivocally that this mode of therapy, as with other therapeutic modalities, is really effective in the treatment of canine papillomatosis.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Cryosurgery / methods
  • Cryosurgery / veterinary*
  • Dog Diseases / surgery*
  • Dogs
  • Male
  • Papilloma / surgery
  • Papilloma / veterinary*
  • Skin Neoplasms / surgery
  • Skin Neoplasms / veterinary*