New brefeldins and penialidins from marine fungus Penicillium janthinellum DT-F29

Xiangwei Cheng; Liyan Yu; Qianqian Wang; Wanjing Ding; Zhe Chen; Zhongjun Ma

doi:10.1080/14786419.2017.1354188

New brefeldins and penialidins from marine fungus Penicillium janthinellum DT-F29

Nat Prod Res. 2018 Feb;32(3):282-286. doi: 10.1080/14786419.2017.1354188. Epub 2017 Jul 19.

Authors

Xiangwei Cheng¹, Liyan Yu², Qianqian Wang², Wanjing Ding², Zhe Chen³, Zhongjun Ma²

Affiliations

¹ a Department of Criminal Science and Technology , Zhejiang Police College , Hangzhou , P. R. China.
² b Institute of Marine Biology , Ocean College, Zhejiang University , Zhoushan , China.
³ c Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology , Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University , Hangzhou , China.

PMID: 28722499
DOI: 10.1080/14786419.2017.1354188

Abstract

A fermentation of marine fungus Penicillium janthinellum DT-F29 on solid rice medium led to the isolation of three new compounds, brefeldin D (1) and penialidins D-E (5-6), along with other five known brefeldins and penialidins. The structures of above compounds were determined on the basis of MS and NMR analysis.

Keywords: Brefeldins; Penicillium janthinellum DT-F29; penialidins.

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology
Aquatic Organisms
Culture Media
Fermentation
Macrolides / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Oryza
Penicillium / chemistry*
Penicillium / growth & development
Polyketides / chemistry*

Substances

Anti-HIV Agents
Culture Media
Macrolides
Polyketides