Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism

Eur Rev Med Pharmacol Sci. 2017 Jun;21(2 Suppl):51-59.


Objective: Clinical evidence suggests that oral supplementation with myo-inositol (MI) and selenium (Se) is useful in the treatment of autoimmune thyroiditis. The purpose of this study was to highlight the positive response of Hashimoto's patients with subclinical hypothyroidism (SH) treated with MI and Se (MI-Se) in restoring a normal thyroid function.

Patients and methods: A total of 168 patients with Hashimoto's thyroiditis (HT) having Thyroid Stimulating Hormone (TSH) levels between 3 and 6 µIU/ml were randomized into 2 groups: one receiving MI-Se and the other one Se alone.

Results: TSH, anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels were significantly decreased in patients treated with combined MI-Se after six months of treatment. Also, a significant free serum T4 increase was observed in MI-Se group, along with an amelioration of patients' quality of life.

Conclusions: The administration of MI-Se is significantly effective in decreasing TSH, TPOAb and TgAb levels, as well as in enhancing thyroid hormones and personal wellbeing. Such treatment restored euthyroidism in patients diagnosed with autoimmune thyroiditis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Autoantibodies / blood
  • Autoantigens
  • Drug Therapy, Combination
  • Female
  • Hashimoto Disease / blood
  • Hashimoto Disease / complications*
  • Hashimoto Disease / drug therapy*
  • Humans
  • Hypothyroidism / complications*
  • Hypothyroidism / drug therapy*
  • Inositol / therapeutic use*
  • Iodide Peroxidase / immunology
  • Iron-Binding Proteins
  • Male
  • Prodromal Symptoms
  • Quality of Life
  • Selenium / therapeutic use*
  • Thyroid Function Tests
  • Thyroid Hormones
  • Thyrotropin / blood
  • Thyroxine / blood
  • Young Adult


  • Autoantibodies
  • Autoantigens
  • Iron-Binding Proteins
  • Thyroid Hormones
  • anti-thyroglobulin
  • Inositol
  • Thyrotropin
  • TPO protein, human
  • Iodide Peroxidase
  • Selenium
  • Thyroxine