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. 2017 Aug;23(8):1419-1421.
doi: 10.3201/eid2308.170162.

mcr-1 and blaKPC-3 in Escherichia coli Sequence Type 744 after Meropenem and Colistin Therapy, Portugal

Marta Tacão, Rafael Dos Santos Tavares, Pedro Teixeira, Inês Roxo, Elmano Ramalheira, Sónia Ferreira, Isabel Henriques

mcr-1 and blaKPC-3 in Escherichia coli Sequence Type 744 after Meropenem and Colistin Therapy, Portugal

Marta Tacão et al. Emerg Infect Dis. 2017 Aug.

Abstract

Escherichia coli Ec36 was recovered from a patient in Portugal after treatment with meropenem and colistin. Besides an IncF plasmid with Tn1441d-blaKPC-3, already reported in clinical strains in this country, E. coli Ec36 co-harbored an IncX4::mcr-1 gene. Results highlight emerging co-resistance to carbapenems and polymyxins after therapy with drugs from both classes.

Keywords: IncX4::mcr-1, IncF::Tn1441d- blaKPC-3, sequence type, Escherichia coli ST744, Klebsiella pneumoniae, multiresistance, Portugal, bacteria; gene, carbapenem, meropenem, colistin, polymixin, fluconazole, linezolid, co-resistance, antimicrobial resistance, antibacterial, antibiotic.

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References

    1. Liu Y-Y, Wang Y, Walsh TR, Yi L-X, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2015;3099:1–8. - PubMed
    1. Skov RL, Monnet DL. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill. 2016;21:30155. 10.2807/1560-7917.ES.2016.21.9.30155 - DOI - PubMed
    1. Dallenne C, Da Costa A, Decré D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2010;65:490–5. 10.1093/jac/dkp498 - DOI - PubMed
    1. Chen L, Chavda KD, Melano RG, Hong T, Rojtman AD, Jacobs MR, et al. Molecular survey of the dissemination of two blaKPC-harboring IncFIA plasmids in New Jersey and New York hospitals. Antimicrob Agents Chemother. 2014;58:2289–94. 10.1128/AAC.02749-13 - DOI - PMC - PubMed
    1. Rodrigues C, Bavlovič J, Machado E, Amorim J, Peixe L, Novais Â. KPC-3-producing Klebsiella pneumoniae in Portugal linked to previously circulating non-CG258 lineages and uncommon genetic platforms (Tn4401d-IncFIA and Tn4401d-IncN). Front Microbiol. 2016;7:1000. 10.3389/fmicb.2016.01000 - DOI - PMC - PubMed

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