A targeted delivery strategy for the development of potent trypanocides

Chem Commun (Camb). 2017 Aug 11;53(62):8735-8738. doi: 10.1039/c7cc03378h. Epub 2017 Jul 20.

Abstract

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite.