New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota

Gut Microbes. 2017 Nov 2;8(6):616-620. doi: 10.1080/19490976.2017.1353842. Epub 2017 Aug 3.


Gut microbiota has been revealed to play an important role in various health conditions, and recent studies have suggested the modulation of gut microbiota as a therapeutic strategy. There is no effective treatment of norovirus infection, though vitamin A has been suggested to have an antiviral effect in an epidemiological study. We demonstrated that vitamin A significantly inhibited murine norovirus replication. Vitamin A supplementation significantly increased the abundance of Lactobacillus sp. during norovirus infection, which played a crucial role in antiviral efficacy, inhibiting murine norovirus. Therefore, we elaborated the antiviral effect of vitamin A via modulation of gut microbiota. Furthermore, we suggest a novel strategy, using potential probiotics, as having a protective and therapeutic effect on noroviral infection.

Keywords: IFN-β; Lactobacillus; gut microbiome; norovirus; vitamin A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Caliciviridae Infections / drug therapy
  • Caliciviridae Infections / microbiology
  • Dysbiosis / drug therapy
  • Dysbiosis / microbiology
  • Gastrointestinal Microbiome / drug effects*
  • Humans
  • Lactobacillus / physiology
  • Norovirus / drug effects*
  • Probiotics
  • Virus Replication / drug effects
  • Vitamin A / pharmacology*


  • Antiviral Agents
  • Vitamin A