The etiology and pathogenesis of sleep obstructive apnea hypopnea syndrome (OSAHS) is not yet definitive, evidence shows that the dysfunction of pharyngeal nerve and the atonia of the muscle innervated by these nerve could play an important role in the progress of OSAHS. Dopamine is a neurotransmitter in the central nervous system which significantly affects the sleep-awake regulation. So far mounting evidence shows that dopamine has a potential role in the modulation of hypoglossal nucleus. The progress of dopamine in obstructive sleep apnea hypopnea syndrome is reviewed in this article.
阻塞性睡眠暂停低通气综合征(OSAHS)的发病机制仍未完全明确，有证据表明咽部肌肉和神经的功能下降可能在OSAHS发生过程中起重要作用，而舌下神经核直接控制着对主要咽部肌肉——颏舌肌的神经输出量。多巴胺是在睡眠调节中发挥重要作用的神经递质。目前大量证据表明多巴胺对舌下神经核存在潜在的调控作用。本文就多巴胺在睡眠呼吸障碍研究进展方面做一综述。.
Keywords: Dopamine; Hypoglossal nerve; Parkinson disease; Sleep apnea, obstructive.