Understanding the genetics behind complex human disease with large-scale iPSC collections

Amanda E Yamasaki; Athanasia D Panopoulos; Juan Carlos Izpisua Belmonte

doi:10.1186/s13059-017-1276-1

Understanding the genetics behind complex human disease with large-scale iPSC collections

Genome Biol. 2017 Jul 20;18(1):135. doi: 10.1186/s13059-017-1276-1.

Authors

Amanda E Yamasaki¹, Athanasia D Panopoulos², Juan Carlos Izpisua Belmonte³

Affiliations

¹ Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA.
² Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA. apanopou@nd.edu.
³ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. belmonte@salk.edu.

Abstract

Three recent studies analyzing large-scale collections of human induced pluripotent stem cell lines provide valuable insight into how genetic regulatory variation affects cellular and molecular traits.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation
Disease*
Genetic Variation*
Humans
Induced Pluripotent Stem Cells*
Models, Genetic*

Abstract

Publication types

MeSH terms

Grants and funding