Influence of childhood trauma on diagnosis and substance use in first-episode psychosis

S Tomassi; S Tosato; V Mondelli; C Faravelli; A Lasalvia; G Fioravanti; C Bonetto; A Fioritti; C Cremonese; R Lo Parrino; K De Santi; A Meneghelli; S Torresani; G De Girolamo; E Semrov; M Pratelli; D Cristofalo; M Ruggeri; GET UP Group

doi:10.1192/bjp.bp.116.194019

Influence of childhood trauma on diagnosis and substance use in first-episode psychosis

Br J Psychiatry. 2017 Sep;211(3):151-156. doi: 10.1192/bjp.bp.116.194019. Epub 2017 Jul 20.

Authors

S Tomassi¹, S Tosato², V Mondelli¹, C Faravelli¹, A Lasalvia¹, G Fioravanti¹, C Bonetto¹, A Fioritti¹, C Cremonese¹, R Lo Parrino¹, K De Santi¹, A Meneghelli¹, S Torresani¹, G De Girolamo¹, E Semrov¹, M Pratelli¹, D Cristofalo¹, M Ruggeri¹; GET UP Group

Affiliations

¹ Simona Tomassi, MD, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona; Sarah Tosato, MD PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, and Unit of Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona; Valeria Mondelli, MD PhD, Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Carlo Faravelli, MD, Department of Psychiatry, University of Firenze, Florence; Antonio Lasalvia, MD PhD, Unit of Psychiatry, AOUI, Verona; Giulia Fioravanti, PhD, Department of Psychiatry, University of Firenze, Florence; Chiara Bonetto, PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Angelo Fioritti, MD, Department of Mental Health, Azienda Unità Sanitario Locale (AUSL) Bologna, Bologna; Carla Cremonese, MD, Unit of Psychiatry, Azienda Ospedaliera Padova, Padua; Riccardo Lo Parrino, MD, Department of Mental Health, Florence; Katia De Santi, MD, Unit of Psychiatry, AOUI, Verona; Anna Meneghelli, Ospedale Niguarda Ca' Granda Milano, MHD Programma 2000, Milan; Stefano Torresani, MD, Department of Mental Health, Bolzano; Giovanni De Girolamo, MD, St John of God Clinical Research Centre of Brescia, Brescia; Enrico Semrov, MD, Department of Mental Health, Reggio Emilia; Michela Pratelli, MD, Department of Mental Health, Riccione; Doriana Cristofalo, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Mirella Ruggeri, MD PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, and Unit of Psychiatry, AOUI, Verona, Italy; the GET UP Group.
² Simona Tomassi, MD, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona; Sarah Tosato, MD PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, and Unit of Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona; Valeria Mondelli, MD PhD, Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Carlo Faravelli, MD, Department of Psychiatry, University of Firenze, Florence; Antonio Lasalvia, MD PhD, Unit of Psychiatry, AOUI, Verona; Giulia Fioravanti, PhD, Department of Psychiatry, University of Firenze, Florence; Chiara Bonetto, PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Angelo Fioritti, MD, Department of Mental Health, Azienda Unità Sanitario Locale (AUSL) Bologna, Bologna; Carla Cremonese, MD, Unit of Psychiatry, Azienda Ospedaliera Padova, Padua; Riccardo Lo Parrino, MD, Department of Mental Health, Florence; Katia De Santi, MD, Unit of Psychiatry, AOUI, Verona; Anna Meneghelli, Ospedale Niguarda Ca' Granda Milano, MHD Programma 2000, Milan; Stefano Torresani, MD, Department of Mental Health, Bolzano; Giovanni De Girolamo, MD, St John of God Clinical Research Centre of Brescia, Brescia; Enrico Semrov, MD, Department of Mental Health, Reggio Emilia; Michela Pratelli, MD, Department of Mental Health, Riccione; Doriana Cristofalo, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Mirella Ruggeri, MD PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, and Unit of Psychiatry, AOUI, Verona, Italy; the GET UP Group sarah.tosato@univr.it.

PMID: 28729356
DOI: 10.1192/bjp.bp.116.194019

Abstract

BackgroundChildhood trauma has been significantly associated with first-episode psychosis, affective dysfunction and substance use.AimsTo test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use.MethodThe sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d. = 9.7).ResultsSevere sexual abuse was significantly associated with a diagnosis of affective psychosis (χ² = 4.9, P = 0.04) and with higher rates of lifetime use of cannabis (68% v 41%; P = 0.02) and heroin (20% v 5%; P = 0.02). Severe physical abuse was associated with increased lifetime use of heroin (15% v 5%; P = 0.03) and cocaine (32% v 17%; P = 0.05).ConclusionsPatients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.

Publication types

Multicenter Study
Randomized Controlled Trial

MeSH terms

Adult
Adult Survivors of Child Adverse Events / classification
Adult Survivors of Child Adverse Events / statistics & numerical data*
Comorbidity
Female
Humans
Italy / epidemiology
Male
Psychotic Disorders / epidemiology*
Substance-Related Disorders / classification
Substance-Related Disorders / epidemiology*
Young Adult