Safety of nitric oxide added to the ECMO circuit: a pilot study in children

Roberto Chiletti; Steve Horton; Andrzej Bednarz; Robert Bartlett; Warwick Butt

doi:10.1177/0267659117720495

Safety of nitric oxide added to the ECMO circuit: a pilot study in children

Perfusion. 2018 Jan;33(1):74-76. doi: 10.1177/0267659117720495. Epub 2017 Jul 21.

Authors

Roberto Chiletti¹, Steve Horton², Andrzej Bednarz³, Robert Bartlett⁴, Warwick Butt¹

Affiliations

¹ 1 Department of Intensive Care, Royal Children's Hospital, Melbourne, Australia.
² 2 Perfusion Department, Royal Children's Hospital, Melbourne, Australia.
³ 3 Department of Biomedical Engineering, Royal Children's Hospital, Melbourne, Australia.
⁴ 4 Department of Surgery, University of Michigan, Ann Arbor, USA.

PMID: 28730947
DOI: 10.1177/0267659117720495

Abstract

We describe our experience of 30 consecutive children supported with ECMO and receiving 20 ppm of nitric oxide in the oxygenator of the ECMO circuit. Administration of nitric oxide into the ECMO circuit is safe and could potentially mitigate ischaemia reperfusion injury and end-organ dysfunction of children requiring mechanical support.

Keywords: ECMO; bleeding; ischaemia reperfusion injury; nitric oxide; outcome.

Publication types

Case Reports

MeSH terms

Child
Extracorporeal Membrane Oxygenation / methods*
Humans
Nitric Oxide / pharmacology
Nitric Oxide / therapeutic use*
Pilot Projects

Substances

Nitric Oxide